A tiny ingestible sensor can measure temperature from inside the body
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Close Caption: “We combined all of these different pieces together — the silicon chip, the battery, and the antenna — and we made it into an ingestible capsule, which is the smallest ingestible capsule that we have seen for temperature-sensing paradigms,” Saransh Sharma says. Credits: Image: Courtesy of the researchers; MIT News Previous image Next image In a hospital or at home, temperatures are usually taken using an oral or forehead thermometer, but these do not always accurately reflect the core body temperature. Measuring core temperature from within the body could make it easier to determine whether someone is sick, and whether they’re at risk of spiking a dangerous fever.
To make it more feasible to obtain core body temperature measurements, MIT engineers have developed an ingestible sensor that can send continuous temperature updates from the GI tract. The sensor is shaped like a tiny blueberry, 6 millimeters in diameter and 4 millimeters in height. That makes it much smaller than existing ingestible temperature sensors, which are more difficult to swallow and pose a potential risk of obstructing the GI tract. “A sensor like this gives us the ability to monitor infections and identify them early,” says Giovanni Traverso, an associate professor of mechanical engineering at MIT, a gastroenterologist at Brigham and Women’s Hospital, and an associate member of the Broad Institute of MIT and Harvard.
“That’s very relevant, particularly for at-risk populations like people who are immunosuppressed from chemotherapy treatments or immunosuppressive drugs.” Ingestible sensors could also enable more accurate temperature measurements for fertility tracking, and for monitoring people during anesthesia. Traverso and Anantha Chandrakasan, MIT’s provost and the Vannevar Bush Professor of Electrical Engineering and Computer Science, are the senior authors of the new study. MIT postdoc Saransh Sharma is the lead author of the paper, which appears today in Nature Electronics.
A handful of ingestible temperature sensors have become commercially available in recent years, but most are the size of a multivitamin or slightly larger, making them more challenging to swallow. Their size can also increase the risk of obstructing the GI tract.
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